Getting My ceesdekker.net To Work

Getting My ceesdekker.net To Work

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‘Sure, that may be about proper. I try to find a physical knowledge of Organic systems in the base-up way. I think you may distinguish a few strains of analysis in my team for the time being. The 1st considerations chromosome framework: How does one obtain a metre-prolonged DNA polymer folded and organised in this kind of microscopic mobile? We've designed visualisation procedures that permit us to study how, such as, SMC proteins loop DNA (video on Youtube) in order to Create up chromosomes.

1996, initially mesoscopic charge density waves gadgets; and initially electrical measurements on just one steel nanocluster concerning nanoelectrodes

Multicolor imaging in the bacterial nucleoid and cell division proteins with blue, orange, and in the vicinity of-infrared fluorescent proteins

Given that 2000, Dekker has shifted the most crucial concentrate of his operate to biophysics exactly where he reports the Attributes of single biomolecules and cells using the instruments of nanotechnology. This alteration of field was driven by his fascination to the extraordinary functioning of biological molecular structures, and also because of the long-term viewpoint that lots of appealing discoveries is usually expected On this discipline.[5] Recent traces of exploration in his biophysics team are during the parts of:[six]

2015, discovery that condensin is usually a remarkably versatile protein structure; and initially detection of DNA knots employing nanopores

SMC complexes can go Actual physical roadblocks bigger than their ring dimension, indicating a nontopological mechanism for DNA loop extrusion

Numerous linked developments followed, in which our group proven diverse transistor variants which include one-electron transistors at home temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled multiple transistors into little proof-of-principle electronic circuits.

2011, to start with in vitro measurements of transportation across an individual biomimetic nuclear pore intricate; growth of multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination

‘You shouldn't just give thought to the thoughts of tomorrow, but also consider the questions of the working day just after tomorrow’

Dekker started his investigate on solitary carbon nanotubes in 1993 when he set up a completely new line of investigation to study electrical transportation by means of single organic and natural molecules in between nanoelectrodes. In 1996 a breakthrough was recognized with carbon nanotubes. ceesdekker This was accomplished inside of a collaboration Together with the group of Nobel laureate Richard Smalley. STM and nanolithography tactics had been utilized to show that these nanotubes are quantum wires at The one-molecule degree, with superb Bodily properties.

Given that 2000 he moved to one-molecule biophysics and nanobiology, with analysis from experiments of DNA loop extrusion and supercoiling to DNA translocation via nanopores. Additional lately his investigation has centered on studying chromatin framework and mobile division with bacteria on chip, even though he is usually attempting to eventually Make artificial cells from the bottom up.

Cees Dekker is Distinguished College Professor at TU Delft. Skilled as being a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes during the nineties. Considering that 2000, he moved to single-molecule biophysics and nanobiology. His present-day exploration focuses on (i) nanopores for protein sequencing; (ii) chromosome structure, especially SMC motor protein; and (iii) creating a living artificial cell from lifeless molecules. Dekker can be an elected member with the KNAW and fellow on the APS and also the IOP.

2008, initial observation of protein-coated DNA translocation through nanopores; fixed the origin on the electrophoretic power on DNA in nanopores; found an important velocity raise of microtubules in electrical fields; found an anomalous electro-hydrodynamic orientation of microtubules; and fixed the origin of sound in carbon nanotubes in liquid

2013, managed shaping of live bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations during the handedness of histone tetrasomes